How to synthesize biocompatible bicyclic peptides?

In recent years, manmade chemicals and biochemical components have contributed immensely to synthesizing new drugs and medicines. They not only possess the desired characteristics needed to manufacture the medicines but also reduce the costs of procuring raw materials from different vendors or natural sources.

Besides, with advancements in technology and evolutionary practices, drug synthesis and formulation have become easier for the global pharma industry.

Owing to this, students pursuing any course related to chemistry, medicine, or biochemistry in Australia often receive assignments based on these new, evolutionary components and technologies that have set the benchmark quite high for the pharma industry.

One such popular topic that has got the limelight is the synthesis process of biocompatible bicyclic peptides. Students often have to conceptualize content based on research papers, whitepapers, and even review articles on this specific topic during their academic years.

While working on a new topic sounds quite tempting, it’s quite difficult for students to gather information and compile it together while adhering to the academic standards simultaneously.

If you also struggling with your project and planning to seek biology assignment help, it would be best to know at least the basics of biocompatible bicyclic peptides and their synthesis process. 

What Are Biocompatible Bicyclic Peptides?

Known to be a new class of peptides developed artificially in laboratories, biocompatible bicyclic peptides are positioned somewhere between small molecules and larger antibodies.

They are considered to be quite stable due to their smaller size while exhibiting excellent target selectivity owing to their binding property with targeted or selected proteins.

Thanks to their cyclic structure, they can easily bind to biological molecules, like protein chains forming an organism.

Since they are meant to be compatible with biological molecules, pharmaceutical companies can develop drugs and medicines that won’t cause any adverse reaction on the cells and tissues. 

What Are The Key features of biocompatible bicyclic peptides?

Although professional essay writing help can help you overcome the challenges in completing your project on biocompatible bicyclic peptides, you should at least know about the same to ensure the work handed to you is accurate and worthy of submission.

So, to help you gain a foothold on this topic, we have described a couple of salient features of biocompatible bicyclic peptides that have made them the new savior of the pharma industry. 

• Stable structure: Since the biocompatible bicyclic peptides have a cyclic chain, they are quite resistant to chemical degradation caused by enzymes. As a result, they can be easily placed within different biochemical environments without having to worry about their reduced performance on target proteins. 

• Reduced immunogenicity: One of the many reasons for which biocompatible bicyclic peptides are being used in therapeutic drug synthesis is their ability to decrease immune response against any foreign body entering the biological body. 

• Increased binding power: Since these compounds have a cyclic structure, their conformations are more profound and well-defined. Owing to this, they can easily bind with different target proteins, enzymes, and receptor cells. In other words, they will be able to work on biochemical products easily and ensure the drugs work their magic as per the expectations.

• Lower toxicity: The toxicity level of biocompatible bicyclic peptides is quite low, making them ideal for drug synthesis and administration to humans and animals alike. They do not cause any adverse reaction with the enzymes and other forms of biochemical compounds present in an organism. 

• Targeted delivery: The biocompatible bicyclic peptides can be engineered to ensure they are delivered to the correct location, thereby increasing their binding affinity with certain biomarkers, like enzyme chains, cells, tissues, and receptors. 

How to synthesize the biocompatible bicyclic peptides?

Owing to the advanced features of biocompatible bicyclic peptides, they are being synthesized at a large scale across the pharmaceutical industry.

In fact, they are also used in several research works to understand their hidden potential in disease treatment and therapeutic healing. Below, we have briefly described its synthesis process. 

• Solid-phase peptide synthesis: First, you need to synthesize a solid-phase peptide linear chain. Begin with choosing a solid resin that is compatible with the targeted amino acids. Once done, you can add each amino acid sequentially to form a linear peptide chain using coupling techniques. Also, it’s important to remove the protecting groups after adding each new amino acid molecule. 

• Cyclization: You need to create the cyclic structure of the linear peptide chain created. For this, you can either opt for side chain to side chain or head-to-tail cyclization strategy. It’s important to use reducing agents or certain catalysts that will help in forming the bond between the N and C terminus or the side chains of the peptide chain. 

• Purification: The cyclic peptide needs to be removed from the resin and exposed to further purification through techniques like high-performance liquid chromatography that will eliminate unwanted substances. 

• Characterization: NMR spectroscopy, mass spectrometry, or HPLC are used for analytical analysis and confirmation of the purity and structure of the designed biocompatible bicyclic peptide chain. 

• Biocompatibility testing: Lastly, the peptides are tested in different biological and biochemical environments to ensure higher compatibility with different enzymes, receptor cells, targeted proteins, and many more. 

Conclusion 

While biocompatible bicyclic peptides might seem to be extremely complicated for you, studying and researching will help you gather detailed information for your project.

If you are having a time crunch or not being able to understand the depth of the topic, you can easily seek help in my assignment from Digi Assignment. 

 

Top Blogs